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Updated: Jul 21, 2026

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[Effect of various cytologic preparation techniques on form, texture and densitometric nuclear parameters of normal
M Oberholzer1, M Hubler, M Hell
1Institut für Pathologie der Universität Basel.
Abstract:
An important prerequisite for densitometric and morphometric measurements on cytological specimens is the standardized cell preparation. Optimal results can only be achieved when the analyses are carried out on a regular monolayer of cell nuclei. Comparing the conventional cytological smear with a new centrifugation technique we demonstrate statistically significant differences of the two methods in texture, size and parameters describing the DNA content of normal and dysplastic urothelial cells.
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