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Standardized precision radiotherapy in choroidal metastases
1Department of General Oncology, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Acta Oncologica (Stockholm, Sweden)
|January 1, 1994
Summary
Precision radiotherapy effectively treated choroidal metastases in 82% of eyes, stabilizing or improving vision. This technique minimized side effects like radiation cataract and dry eye, avoiding surgery for most patients.
Area of Science:
- Ophthalmology
- Radiation Oncology
- Medical Physics
Background:
- Choroidal metastases are common in advanced cancers, often causing visual impairment.
- Existing treatments may have significant side effects or limited efficacy.
- Precision radiotherapy offers a targeted approach to ocular tumors.
Purpose of the Study:
- To evaluate the efficacy and safety of a precision radiotherapy technique for choroidal metastases.
- To assess the impact on visual acuity and the need for surgical intervention.
- To determine the incidence of treatment-related side effects.
Main Methods:
- 17 consecutive patients with symptomatic choroidal metastases were treated using a standardized precision radiotherapy technique.
- A beam-defining collimator and individually fixed eye positioning were employed.
- Varying fractionations and doses were administered, with biologically effective doses (BED) ranging from 47-90 Gy (BED3) and 28-59 Gy (BED10).
Main Results:
- Complete regression of choroidal metastases was observed in 14 eyes (82%).
- Visual acuity was stabilized or improved in all treated patients.
- No patients required local surgery; only three developed radiation retinopathy, with vision compromised in one case.
Conclusions:
- The standardized precision radiotherapy technique is highly effective in regressing choroidal metastases.
- The treatment preserves or enhances visual function and avoids the need for surgery.
- This method minimizes risks of radiation cataract and dry eye, simplifying treatment planning.