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CCK-containing paraneurons in human adenomatous prostate
A Cecio1, T Cocca, M T Masotti
1Dept. of Structures, Functions and Biological Technology, University of Naples, Italy.
Bioscience Reports
|October 1, 1993
Summary
Neuroendocrine cells containing cholecystokinin (CCK) and serotonin were found in human prostate adenomas. These cells may influence urogenital tract functions like muscle contraction and secretions.
Area of Science:
- Urology
- Endocrinology
- Cell Biology
Background:
- Neuroendocrine cells play roles in various physiological processes.
- The specific function of neuroendocrine cells in the prostate is not fully understood.
Purpose of the Study:
- To investigate the presence and characteristics of cholecystokinin (CCK)-containing neuroendocrine cells in human prostate adenomas.
- To determine the colocalization of CCK with other neuroendocrine markers, such as serotonin.
Main Methods:
- Immunohistochemical techniques were employed to detect CCK.
- Double labeling immunofluorescent staining was used to assess colocalization with serotonin.
Main Results:
- CCK-containing neuroendocrine cells were identified in human adenomatous prostates.
- A significant colocalization (96.55%) of CCK with serotonin within the same cells was observed.
- These cells exhibited focal distribution and sometimes possessed dendrite-like cytoplasmic processes.
Conclusions:
- CCK-containing neuroendocrine cells are present in human prostate adenomas.
- The colocalization with serotonin suggests a potential shared regulatory role.
- CCK may stimulate muscle contraction and endocrine/exocrine secretions in the urogenital tract.