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[Synovial angiogenesis]

F Lioté1

  • 1Centre Viggo Petersen (clinique de rhumatologie et laboratoire d'histopathologie de la synoviale) hôpital Lariboisière, Paris.

La Revue Du Praticien
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Synovial angiogenesis, the growth of new blood vessels in joints, persists in rheumatoid arthritis (RA) and drives disease progression. Inhibiting this process could offer new therapeutic strategies for RA patients.

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Area of Science:

  • Rheumatology
  • Vascular Biology
  • Pathophysiology

Context:

  • Synovial angiogenesis, new capillary formation, is key in joint inflammation.
  • Normally resolves post-inflammation, but persists in chronic conditions like rheumatoid arthritis (RA).
  • RA is characterized by persistent synovial angiogenesis, termed an 'angiogenic disease'.

Purpose:

  • To highlight the role of synovial angiogenesis in rheumatoid arthritis pathogenesis.
  • To explain the mechanisms driving persistent angiogenesis in RA.
  • To propose therapeutic strategies targeting synovial angiogenesis in RA.

Summary:

  • Synovial angiogenesis, crucial in articular inflammation, persists in rheumatoid arthritis (RA) due to biochemical events.
  • These events degrade the extracellular matrix and release angiogenic factors, fueling pannus growth.

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  • This pannus growth, dependent on angiogenesis, leads to joint cartilage destruction.

    • Impact:

    • Understanding RA as an 'angiogenic disease' opens new therapeutic avenues.
    • Developing inhibitors of synovial angiogenesis offers hope for RA treatment.
    • Targeting angiogenesis may halt or reverse joint damage in rheumatoid arthritis.