Related Experiment Videos
Anti-allergy actions of alkylphenyl alpha-D-mannopyranosides
T C Wang1, H Kakegawa, H Matsumoto
1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Biological & Pharmaceutical Bulletin
|January 1, 1994
Abstract:
The inhibitory effects of alkylphenyl alpha-D-mannopyranosides on histamine release from rat peritoneal mast cells induced by an antigen-antibody reaction were examined. Among the compounds tested, 2,4,6-trimethylphenyl alpha-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, the 2,4,6-trimethylphenyl alpha-D-mannopyranoside suppressed the Schultz-Dale reaction and 48 h homologous passive cutaneous anaphylaxis (PCA), suggesting that this compound may be a useful lead compound in the development of novel anti-allergy drugs.