Synthesis and inverse emulsion polymerization of aminated acrylamidodextran

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Drug Delivery Systems

Background:

• Dextran is a versatile polysaccharide with potential in biomedical applications.
• Chemical modification is required to impart new functionalities, such as polymerizability and reactive groups.
• Developing novel biomaterials for drug conjugation and surface modification is crucial for advanced therapeutics.

Purpose of the Study:

• To synthesize a novel dextran derivative with both a polymerizable acrylamide moiety and reactive primary amine groups.
• To investigate the polymerization of the modified dextran using inverse emulsion polymerization.
• To prepare submicron particles from the modified dextran for potential applications in drug delivery and biomaterial surface engineering.

Main Methods:

• Dextran activation using 4-nitrophenyl-chloroformate to introduce carbonate linkages.
• Sequential coupling with trityldiaminoethane and acryloamidodiaminohexane to introduce amine and acrylamide functionalities.
• Trityl group removal via acid hydrolysis to yield aminated acryloamidodextran.
• Inverse emulsion polymerization to form submicron particles.

Main Results:

• Successfully synthesized aminated acryloamidodextran with controlled functionalization.
• Demonstrated the polymerizability of the modified dextran via inverse emulsion polymerization.
• Prepared submicron particles with accessible primary amine groups on their surface.

Conclusions:

• The synthesized aminated acryloamidodextran is a promising functional biomaterial.
• The resulting submicron particles offer a platform for developing drug conjugates.
• The material's amine groups allow for versatile surface property modifications.