Related Experiment Videos
Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells
T Ono1, M Norimatsu, H Yoshimura
1National Veterinary Assay Laboratory, Tokyo, Japan.
Mutation Research
|April 1, 1994
Abstract:
Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine. Pyrimethamine without metabolic activation strongly induced structural chromosome aberrations in a dose-dependent manner. Aberrant metaphase cells occurred at a frequency of 80%, when cells were treated at 1.6 microgram/ml for 48 h.