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Synthesis and biological activity of NK1 tachykinin antagonists not containing D-residues
C Poulos1, M Antoniou, R Patacchini
1Department of Chemistry, University of Patras, Greece.
Neuropeptides
|January 1, 1994
Abstract:
A series of analogues of the previously reported NK1 tachykinin antagonist [Orn6, Glu(OBzl)11]-SP6-11-OBzl has been synthesized and tested in order to investigate the effects on antagonistic activity of modifications at the C-terminal residue. The biological activity in the guinea-pig ileum assay (NK1 receptor) indicates that the two aromatic rings introduced in the C-terminal part of the peptide are both essential for the expression of antagonistic activity.