Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antacids. Indications and limitations

C K Ching1, S K Lam

  • 1Department of Medicine, University of Hong Kong, Queen Mary Hospital.

Drugs
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Another ketamine analogue on the horizon.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Emergence of new psychoactive substance 2-fluorodeschloroketamine: Toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues.

Forensic science international·2020
Same author

Poisoning by toxic plants in Hong Kong: a 15-year review.

Hong Kong medical journal = Xianggang yi xue za zhi·2019
Same author

Sudden arrhythmia death syndrome in young victims: a five-year retrospective review and two-year prospective molecular autopsy study by next-generation sequencing and clinical evaluation of their first-degree relatives.

Hong Kong medical journal = Xianggang yi xue za zhi·2019
Same author

Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.

Forensic science international·2018
Same author

The first pilot study of expanded newborn screening for inborn errors of metabolism and survey of related knowledge and opinions of health care professionals in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2018

Antacids effectively heal duodenal ulcers, with optimal regimens including 400 mmol/day doses. While beneficial for reflux and critical care, their role in dyspepsia is debated, though their long-term safety is unparalleled.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Antacids have been used for over a century for acid-related gastrointestinal disorders.
  • Historical attitudes suggested antacids were only for on-demand use, a notion now challenged by recent evidence.
  • Antacids offer a long-term safety profile unmatched by newer antisecretory agents.

Purpose of the Study:

  • To review the efficacy and appropriate usage of antacids in managing various acid-related gastrointestinal conditions.
  • To compare the benefits and drawbacks of antacids against modern antisecretory medications.

Main Methods:

  • Review of endoscopic controlled studies on antacid efficacy in ulcer healing.
  • Analysis of clinical outcomes in patients with gastro-oesophageal reflux, pregnancy-related reflux, and critical care conditions.

Related Experiment Videos

  • Evaluation of antacid use in nonulcer dyspepsia and NSAID-induced mucosal damage.

    • Main Results:

    • 13 endoscopic studies confirm antacids heal duodenal ulcers in approximately 75% of cases within 4 weeks.
    • Optimal duodenal ulcer treatment involves 400 mmol/day acid neutralizing capacity, taken post-meal.
    • Antacids are effective for gastro-oesophageal reflux, pregnancy-related reflux, aspiration pneumonitis prophylaxis, and reducing bleeding in critically ill patients.
    • Antacid efficacy in gastric ulcer healing is less established and results are controversial.
    • Their role in nonulcer dyspepsia and NSAID-related damage remains debated.

    Conclusions:

    • Antacids remain valuable for treating gastric acid-related disorders, particularly duodenal ulcers and reflux conditions.
    • While newer agents like proton pump inhibitors offer advantages, antacids possess an unsurpassed long-term safety record.
    • Appropriate antacid regimens are crucial for maximizing efficacy and patient compliance.