Pregnancy after treatment of epithelioid hemangioendothelioma. A case report

Pregnancy occurred in a woman who had undergone hepatic, cerebral and myocardial resection of epithelioid hemangioendotheliomas (EHEs). The overall course of her pregnancy did not seem to be affected by the prior EHEs, though the pregnancy was complicated by preterm delivery. The patient was observed to have elevated maternal serum alpha-fetoprotein (MSAFP); a complete workup found no abnormalities in the fetus, and a relationship between the EHEs and elevated MSAFP was not apparent. Because of the unknown contribution of EHE to MSAFP, inclusion of targeted (level II) ultrasound and possibly amniocentesis seem appropriate to prenatally diagnose structural anomalies and ensure a normal karyotype.