Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative thrombogenicity of pacemaker leads

G M Palatianos1, M K Dewanjee, G Panoutsopoulos

  • 1Division of Thoracic and Cardiovascular Surgery, University of Miami School of Medicine, Florida.

Pacing and Clinical Electrophysiology : PACE
|February 1, 1994
PubMed
Summary

This study compared the thrombogenicity of silicone and polyurethane pacemaker leads in pigs. Polyurethane leads showed lower platelet deposits and may be less thrombogenic than silicone leads, suggesting reduced risk of thrombus formation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence, clinical characteristics and the burden of disease of the Croatian adult patients with HAE: nationwide survey analysis.

European annals of allergy and clinical immunology·2026
Same author

Comparison of narrow-band imaging with autofluorescence imaging for endoscopic detection of squamous cell carcinoma of the tonsil.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2023
Same author

Shortening sow restraint period during lactation improves production and decreases hair cortisol concentrations in sows and their piglets.

Animal : an international journal of animal bioscience·2021
Same author

Size of silk fibroin β-sheet domains affected by Ca<sup>2</sup>.

Journal of materials chemistry. B·2020
Same author

The quality of death certification practice in Greece.

Hippokratia·2016
Same author

Examining Opioid-Dependent Chronic Pain Patients Experiences On Buprenorphine Maintenance Therapy In The Texas Workers Compensation System: Pilot Study - Part 2.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Pacemaker lead thrombogenicity is a critical factor in device performance and patient safety.
  • Understanding the interaction between implanted materials and the cardiovascular system is essential for developing safer medical devices.

Purpose of the Study:

  • To evaluate and compare the thrombogenicity of transvenous silicone and polyurethane pacemaker leads.
  • To assess early thrombus formation and embolization associated with these lead materials.

Main Methods:

  • Anesthetized Yorkshire pigs were implanted with silicone or polyurethane pacemaker leads.
  • Autologous indium-111 labeled platelets were injected to track deposition.
  • Gamma camera imaging and gamma counter measurements quantified platelet deposits and radioactivity in lungs.

Related Experiment Videos

Main Results:

  • Platelet deposits were denser on silicone leads compared to polyurethane leads, though not statistically significant (P > 0.05).
  • Higher percentages of injected platelet radioactivity were found in the lungs of pigs with both lead types compared to controls (P < 0.05), indicating thrombus formation and embolization.
  • Platelet deposit density decreased from the tip to distal segments in silicone leads.

Conclusions:

  • Polyurethane pacemaker leads may exhibit lower thrombogenicity than silicone leads.
  • Early thrombus formation and pulmonary embolization occur following pacemaker lead implantation.
  • Material choice for pacemaker leads can influence thrombotic events.