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Related Experiment Videos

Comparative thrombogenicity of pacemaker leads

G M Palatianos1, M K Dewanjee, G Panoutsopoulos

  • 1Division of Thoracic and Cardiovascular Surgery, University of Miami School of Medicine, Florida.

Pacing and Clinical Electrophysiology : PACE
|February 1, 1994
PubMed
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This study compared the thrombogenicity of silicone and polyurethane pacemaker leads in pigs. Polyurethane leads showed lower platelet deposits and may be less thrombogenic than silicone leads, suggesting reduced risk of thrombus formation.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Pacemaker lead thrombogenicity is a critical factor in device performance and patient safety.
  • Understanding the interaction between implanted materials and the cardiovascular system is essential for developing safer medical devices.

Purpose of the Study:

  • To evaluate and compare the thrombogenicity of transvenous silicone and polyurethane pacemaker leads.
  • To assess early thrombus formation and embolization associated with these lead materials.

Main Methods:

  • Anesthetized Yorkshire pigs were implanted with silicone or polyurethane pacemaker leads.
  • Autologous indium-111 labeled platelets were injected to track deposition.
  • Gamma camera imaging and gamma counter measurements quantified platelet deposits and radioactivity in lungs.

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Main Results:

  • Platelet deposits were denser on silicone leads compared to polyurethane leads, though not statistically significant (P > 0.05).
  • Higher percentages of injected platelet radioactivity were found in the lungs of pigs with both lead types compared to controls (P < 0.05), indicating thrombus formation and embolization.
  • Platelet deposit density decreased from the tip to distal segments in silicone leads.

Conclusions:

  • Polyurethane pacemaker leads may exhibit lower thrombogenicity than silicone leads.
  • Early thrombus formation and pulmonary embolization occur following pacemaker lead implantation.
  • Material choice for pacemaker leads can influence thrombotic events.