Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating adhesion molecules in asthma

S Montefort1, C K Lai, P Kapahi

  • 1Department of Immunopharmacology, University of Southampton, Southampton General Hospital, United Kingdom.

American Journal of Respiratory and Critical Care Medicine
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Links between socio-demographic characteristics and body mass index to colorectal cancer in North Borneo, Malaysia: A case-control study.

The Medical journal of Malaysia·2023
Same author

Development of the rural Palliative Care Services by the Kuala Lipis District Hospital.

The Medical journal of Malaysia·2021
Same author

Emergence of new psychoactive substance 2-fluorodeschloroketamine: Toxicology and urinary analysis in a cluster of patients exposed to ketamine and multiple analogues.

Forensic science international·2020
Same author

Ketamine analogues multiplying in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2019
Same author

Cluster of acute poisonings associated with an emerging ketamine analogue, 2-oxo-PCE.

Forensic science international·2018
Same author

Multidrug-resistant organism carriage among residents from residential care homes for the elderly in Hong Kong: a prevalence survey with stratified cluster sampling.

Hong Kong medical journal = Xianggang yi xue za zhi·2018
Same journal

When an Exacerbation Signals a Different Future in non-severe asthma.

American journal of respiratory and critical care medicine·2026
Same journal

Aim High-Stay Stable: Rethinking Treatment Success in COPD.

American journal of respiratory and critical care medicine·2026
Same journal

Three versus six weeks of corticosteroids for mild immune-related pneumonitis: a randomized trial.

American journal of respiratory and critical care medicine·2026
Same journal

Signal in the Noise: Polygenic Scores and the Problem of Defining Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
Same journal

Do mtDNA fragmentomic peaks reflect cancer biology or preanalytical and technical artifacts in NSCLC?

American journal of respiratory and critical care medicine·2026
Same journal

Short for Their Age: Interpreting Whole-Genome Telomere Length in Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
See all related articles

Circulating intercellular adhesion molecule-1 (cICAM-1) and E-selectin (cE-selectin) are elevated in acute asthma, reflecting airway inflammation. Vascular cell adhesion molecule-1 (cVCAM-1) levels did not significantly change.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Biochemistry

Background:

  • Leukocyte-endothelial adhesion molecules are crucial in inflammatory airway diseases.
  • Circulating forms of these molecules (cICAM-1, cE-selectin, cVCAM-1) have been identified, but their roles are unclear.

Purpose of the Study:

  • To quantify circulating intercellular adhesion molecule-1 (cICAM-1), E-selectin (cE-selectin), and vascular cell adhesion molecule-1 (cVCAM-1) in different asthma states.
  • To investigate the relationship between these adhesion molecules and asthma exacerbations.

Main Methods:

  • Antigen capture ELISA was used to measure cICAM-1, cE-selectin, and cVCAM-1 levels.
  • Blood samples were collected from healthy volunteers (atopic and non-atopic) and patients with stable and acute asthma.

Related Experiment Videos

Main Results:

  • cICAM-1 and cE-selectin levels were significantly higher in acute asthma patients compared to stable asthma and healthy controls.
  • No significant differences were observed in cVCAM-1 levels across all groups.
  • No correlations were found among the concentrations of the three measured circulating adhesion molecules.

Conclusions:

  • Elevated cICAM-1 and cE-selectin in acute asthma likely indicate a heightened inflammatory response in the airways.
  • Cytokine and mediator profiles during acute asthma may preferentially stimulate the production of cICAM-1 and cE-selectin over cVCAM-1.