Serum levels of prostate-specific antigen in normal boys throughout puberty

Serum levels of prostate-specific antigen (PSA) were measured in a group of 132 normal boys distributed in stages 1-5 of puberty. A highly sensitive (0.005 ng/mL) immunofluorometric assay was developed and used in the study. PSA levels were generally undetectable in state I and rose sharply from stage II to III and from stage III to IV. A significant positive correlation was found between PSA and testosterone levels, PSA and LH levels, PSA and age, PSA and testicular volume, as well as PSA and pubertal stage. Our findings indicate that PSA levels measured with highly sensitive assays can be of utility in the hormonal evaluation of puberty in boys.