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Hemoglobin variants in India

M Ajmani, A Sharma, G Talukder

    Acta Geneticae Medicae Et Gemellologiae
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Hemoglobin variants like Hb E and Hb D are common in India, particularly in the East and North respectively. Their links with beta-thalassaemia and G6PD deficiency are known, but environmental factors like malaria require further study.

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    Area of Science:

    • Hematology
    • Human Genetics
    • Population Health

    Background:

    • Hemoglobin variants and beta-thalassaemia are prevalent in India, with documented occurrences in urban and tribal populations.
    • Specific variants like Hemoglobin E (Hb E) and Hemoglobin D (Hb D) show regional predilections, with Hb E in the East and Hb D in the North.
    • Established associations exist between Hb E, beta-thalassaemia, and Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency.

    Purpose of the Study:

    • To summarize the current understanding of hemoglobin variant distribution in India.
    • To highlight regional variations in the incidence of specific hemoglobinopathies.
    • To discuss known associations and areas needing further research, such as environmental factors.

    Main Methods:

    • Review of existing epidemiological data on hemoglobin variants in India.

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  • Analysis of prevalence rates and geographical distribution of common hemoglobinopathies.
  • Literature synthesis on associated genetic and potential environmental factors.

    • Main Results:

    • Hemoglobin variants, including beta-thalassaemia, Hb D, Hb E, Hb H, Hb S, and rare variants like Hb Lepore, occur in India.
    • Hb E is more frequent in Eastern India, while Hb D is prevalent in certain Northern populations.
    • Confirmed associations include Hb E with beta-thalassaemia and G6PD deficiency.

    Conclusions:

    • Hemoglobin variants represent a significant public health concern in India with distinct geographical patterns.
    • Further research is needed to elucidate the relationship between hemoglobin variants and environmental factors, such as malaria.