Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Circadian rhythm in allergic inflammation]

C R Baumgarten1, C de Baey, B Siebert

  • 1Abteilung für klinische Immunologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin.

Pneumologie (Stuttgart, Germany)
|February 1, 1994
PubMed
Summary

Allergic disease symptoms worsen at night due to biological rhythms affecting hormones, immune cells, and mediators. Understanding these circadian variations is crucial for effective allergy medication timing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis.

Journal of investigational allergology & clinical immunology·2011
Same author

Effect of fluticasone on neuropeptides in nasal lavage in persistent allergic rhinitis.

Journal of investigational allergology & clinical immunology·2010
Same author

Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis.

Journal of investigational allergology & clinical immunology·2010
Same author

Analysis of the CONRAD computational problems expressing only stochastic uncertainties: neutrons and protons.

Radiation protection dosimetry·2008
Same author

Efficacy and safety of formoterol delivered through the Novolizer, a novel dry powder inhaler (DPI) compared with a standard DPI in patients with moderate to severe asthma.

Pulmonary pharmacology & therapeutics·2007
Same author

Direct detection of bacterial genomic DNA using gold nanoparticle probes.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007

Area of Science:

  • Immunology
  • Endocrinology
  • Chronobiology

Context:

  • Allergic diseases exhibit significant nocturnal symptom exacerbation.
  • This phenomenon is linked to complex bioperiodicities in various physiological systems.

Purpose:

  • To investigate the underlying biological rhythms contributing to nighttime allergy symptom severity.
  • To correlate specific mediator and cellular variations with observed hyperreactivity.

Summary:

  • Significant circadian variations exist for hormonal (cortisol, adrenaline), neural (cyclic AMP), humoral (IgE, IgG, IgM, IgA), and cellular (T-cells, B-lymphocytes) factors.
  • Histamine peaks in the early morning, while adrenaline and cyclic AMP are at their minimum.
  • Bronchial constriction mediators like Thromboxane A2 peak nocturnally, with PGE2 depressed, contributing to nighttime respiratory symptoms.

Related Experiment Videos

Impact:

  • Highlights the critical importance of chronobiology in managing allergic diseases.
  • Provides a basis for optimizing medication timing to improve therapeutic efficacy and patient outcomes.
  • Suggests that personalized treatment schedules based on individual circadian rhythms may enhance symptom control.