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Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells
G Gentilini1, M Grazia di Bello, S Raspanti
1Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
The Journal of Pharmacy and Pharmacology
|January 1, 1994
Abstract:
Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.