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t(12;21): a new recurrent translocation in acute lymphoblastic leukemia
S P Romana1, M Le Coniat, R Berger
1INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Genes, Chromosomes & Cancer
|March 1, 1994
Abstract:
A t(12;21)(p11-p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p- abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21-q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t(12;21) has been reported previously, the present results suggest that t(12;21) is a recurrent translocation in ALL.