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Group II phospholipase A2 in serum in critically ill surgical patients
J M Grönroos1, K Kuttila, T J Nevalainen
1Department of Surgery, University of Turku, Finland.
Objective:
To study the association of increased serum group II phospholipase A2 concentrations to C-reactive protein concentrations in the sera of critically ill surgical patients.
Design:
Prospective study.
Setting:
Surgical intensive care unit (ICU) of a university hospital.
Patients:
Sixty-seven consecutive patients admitted to the surgical ICU.
Interventions:
The catalytic activity of phospholipase A2 and the serum concentrations of group II phospholipase A2 and C-reactive protein were measured daily during each patient's stay in the ICU. A total of 205 blood samples were taken. In addition, the preoperative serum levels of group II phospholipase A2 were determined in patients admitted for cardiac surgery.
Measurements And Main Results:
Serum group II phospholipase A2 values correlated statistically significantly with the catalytic activity of phospholipase A2 and serum C-reactive protein values. In particular, severe infections, diseases involving tissue destruction, and elective operations per se, caused considerable increases in serum group II phospholipase A2 concentrations.
Conclusion:
Our results support the earlier presented idea that group II phospholipase A2 is an acute-phase reactant.