Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Microphonic potentials in guinea pigs with liver damages]

B Kramp, D Dahl

    Archives of Oto-Rhino-Laryngology
    |September 28, 1978
    PubMed
    Summary

    This study in guinea pigs demonstrated that liver damage significantly lowers auditory brainstem response (ABR) potentials by 3.4 dB. These findings correlate with hearing loss observed in human patients suffering from chronic liver disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Intraoral voice recording-towards a new smartphone-based method for vocal rehabilitation. German version].

    HNO·2018
    Same author

    Intraoral voice recording-towards a new smartphone-based method for vocal rehabilitation.

    HNO·2018
    Same author

    Portable Pocket colposcopy performs comparably to standard-of-care clinical colposcopy using acetic acid and Lugol's iodine as contrast mediators: an investigational study in Peru.

    BJOG : an international journal of obstetrics and gynaecology·2018
    Same author

    Introduction of biosimilar insulins in Europe.

    Diabetic medicine : a journal of the British Diabetic Association·2017
    Same author

    Efficacy and safety of LY2963016 insulin glargine in patients with type 1 and type 2 diabetes previously treated with insulin glargine.

    Diabetes, obesity & metabolism·2016
    Same author

    Efficacy and safety of LY2963016 insulin glargine compared with insulin glargine (Lantus®) in patients with type 1 diabetes in a randomized controlled trial: the ELEMENT 1 study.

    Diabetes, obesity & metabolism·2015

    Area of Science:

    • Ototoxicology
    • Hepatology
    • Neuroscience

    Context:

    • Chronic liver disease can lead to systemic complications affecting multiple organs.
    • Auditory function is not commonly considered a primary indicator of liver health.
    • Previous research has not extensively explored the link between liver parenchymal damage and auditory system changes.

    Purpose:

    • To investigate the impact of induced histological liver damage on auditory brainstem response (ABR) potentials in guinea pigs.
    • To correlate animal model findings with potential hearing impairments in human patients with chronic liver disease.

    Summary:

    • Histological liver damage was induced in guinea pigs.
    • Auditory brainstem response potentials were measured and found to be significantly lower (approximately 3.4 dB) in animals with liver damage compared to healthy controls.
    • Experimental results in animals suggest a link between liver damage and inner ear hearing loss, mirroring observations in human patients with chronic liver parenchymal damage.

    Impact:

    • Establishes a potential biomarker (altered ABR potentials) for assessing the severity of liver damage.
    • Highlights the ototoxic potential of liver disease, suggesting hearing health should be monitored in affected patients.
    • Provides a foundation for further research into the mechanisms linking liver dysfunction and auditory pathway pathology.

    Related Experiment Videos