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[Androgen deprivation in benign prostatic hypertrophy]

R Tenaglia1, M Nicolai, G Di Federico

  • 1Division of Urology, University G. D'Annunzio Medical School, Chieli, Italie.

Journal D'Urologie
|January 1, 1993
PubMed
Summary

Benign prostatic hypertrophy (BPH) affects most men over 50, causing urinary obstruction. Androgen deprivation is the only effective hormonal treatment to reduce BPH, with this review detailing endocrine aspects and therapeutic strategies.

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Area of Science:

  • Urology
  • Endocrinology
  • Gerontology

Context:

  • Benign prostatic hypertrophy (BPH) is a common condition causing urinary outflow obstruction in men over 50.
  • BPH pathophysiology involves aging and testicular androgens.
  • Hormonal interventions are crucial for managing BPH.

Purpose:

  • To review the endocrine aspects of benign prostatic hypertrophy.
  • To discuss hormonal treatment strategies for BPH.
  • To evaluate the clinical efficacy and side effects of hormonal therapies for BPH.

Summary:

  • Benign prostatic hypertrophy (BPH) is a leading cause of urinary outflow obstruction in aging men.
  • The development of BPH is linked to testicular androgens and the aging process.
  • Androgen deprivation represents the sole therapeutic approach capable of reducing the hyperplastic state in BPH.

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Impact:

  • Provides a comprehensive overview of the endocrine factors contributing to BPH.
  • Guides clinical decision-making regarding hormonal treatments for BPH.
  • Highlights the importance of considering efficacy and side effects in BPH management.