Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug-induced organic mood disorders]

I Sasaki1, I Fujii

  • 1Department of Neuropsychiatry, Oita Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 1, 1994
PubMed
Summary

Antidepressants can trigger mania in patients with major depression or bipolar disorder, with higher risks observed in bipolar patients. Specific drugs like clomipramine showed increased switch rates, highlighting the need for careful monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes.

Chemical communications (Cambridge, England)·2016
Same author

A Simple Fluorometry of Hydroperoxides in Oils and Foods.

Bioscience, biotechnology, and biochemistry·2016
Same author

Effects of stellate ganglion block on cardiac coronary circulation.

Journal of anesthesia·2013
Same author

Endface index profiling of optical fiber preforms.

Applied optics·2010
Same author

Spatially resolved spectroscopic mapping of polarization reversal in polycrystalline ferroelectric films: crossing the resolution barrier.

Physical review letters·2009
Same author

Quality of life of patients and medical cost of "half elemental diet" as maintenance therapy for Crohn's disease: secondary outcomes of a randomised controlled trial.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2008

Area of Science:

  • Psychiatry
  • Pharmacology
  • Neuroscience

Context:

  • Assessing drug-induced mental disorders presents challenges.
  • Previous literature suggests links between certain drugs (e.g., corticosteroids, interferon) and organic mood disorders.
  • Understanding antidepressant effects on mood states is crucial for patient safety.

Purpose:

  • To review existing literature on drugs associated with organic mood disorders.
  • To investigate the rate of antidepressant-induced mood switching from depression to mania.
  • To determine the time from antidepressant administration to the onset of mania across different patient groups.

Summary:

  • The study examined antidepressant-induced mania switch rates and latency in patients with major depression (single episode, recurrent) and bipolar disorder (depressed).
  • Switch rates were 17.2% (major depression, single episode), 14.3% (major depression, recurrent), and 32.0% (bipolar disorder, depressed).
  • Latency to manic onset did not significantly differ between groups, averaging around 37-70 days. Clomipramine, amitriptyline, imipramine, and dosulepin exceeded a 10% switch rate.

Impact:

  • Findings highlight the risk of antidepressant-induced mania, particularly in bipolar disorder patients.
  • Identifies specific antidepressants with higher switch rates, informing clinical prescribing practices.
  • Emphasizes the need for vigilant monitoring of mood changes during antidepressant treatment.

Related Experiment Videos