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Updated: Oct 16, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
Lactate threshold determination: a Monte Carlo comparison of two interpolation methods
L Laurencelle1, A Quirion, S Nadeau
1Départment des sciences de l'activité physique, Université du Québec à Trois-Rivières, Canada.
Abstract:
A heuristic model of the relation between blood lactate (L) and VO2 during exercise was used to assess the comparative merits of two methods of reference threshold determination: the habitual linear interpolation method (LT), and a new method using inverse parabolic (second degree) interpolation (PT); the new method capitalizes on the demonstrated curvilinear relation between blood lactate and O2 uptake. Both types of interpolated thresholds were computed, and their error evaluated against the "true" 4-mmol lactate threshold. A combined parametric and Monte Carlo investigation showed that parabolic thresholds are generally superior, being less biased and more precise than their linear counterpart.
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