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Effect of platelet activating factor (PAF) on the formation of blood vessels in subcutaneous implants in mice
S P Andrade1, L B Vieira, Y S Bakhle
1Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Journal of Lipid Mediators and Cell Signalling
|March 1, 1994
Abstract:
Angiogenesis accompanies inflammatory processes and many other pathological conditions. We have studied the effect of platelet-activating factor (PAF) a well-known inflammatory mediator, as a promoter of angiogenesis in the sponge implant model in mice. Development of blood vessels and blood flow were monitored by use of a 133Xe washout technique. The results showed PAF to have angiogenic activity, which was inhibited by WEB 2086, and the PAF-induced vasculature to have normal pharmacological reactivity.