Nitric oxide synthase immunoreactivity colocalized with NADPH-diaphorase histochemistry in monkey cerebral cortex

The distributions of reduced nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) containing neurons and the extent of NADPH-d and NOS colocalization have been analyzed by histochemical and immunocytochemical techniques in the neocortex of Macaca fuscata monkeys. NADPH-d positive cells were consistently also NOS positive and presented a relatively uniform distribution from area to area, but area-specific differences were observed in the pattern of distribution of fiber plexuses.