Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capsaicin-induced bladder hyperactivity in normal conscious rats

O Ishizuka1, Y Igawa, A Mattiasson

  • 1Department of Urology, Lund University Hospital, Sweden.

The Journal of Urology
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exogenously administered bombesin and gastrin releasing peptide contract the female rat urethra in vivo and in vitro.

Neurourology and urodynamics·2011
Same author

Guidelines on neurogenic lower urinary tract dysfunction.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2007
Same author

Guidelines on neurogenic lower urinary tract dysfunction.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2007
Same author

Clinical experiences with desmopressin for long-term treatment of nocturia.

The Journal of urology·2004
Same author

The cost of feedback microwave thermotherapy compared with transurethral resection of the prostate for treating benign prostatic hyperplasia.

BJU international·2004
Same author

Simplified bladder training augments the effectiveness of tolterodine in patients with an overactive bladder.

BJU international·2003

Intravesical capsaicin in rats causes bladder hyperactivity, mediated by NK-2 receptors. This effect, mimicking sensory nerve activation, can be blocked by specific antagonists, offering a model for bladder sensory studies.

Area of Science:

  • Neuroscience
  • Urology
  • Pharmacology

Background:

  • Capsaicin activates sensory nerves, including those in the bladder.
  • Bladder hyperactivity is a common urological condition.
  • Tachykinins are neuropeptides involved in sensory neurotransmission.

Purpose of the Study:

  • To investigate the role of capsaicin-sensitive nerves and tachykinin receptors in bladder hyperactivity in rats.
  • To explore the potential of NK-2 receptors in mediating bladder sensory reflexes.

Main Methods:

  • Intravesical capsaicin instillation in conscious, unanesthetized rats.
  • Administration of various antagonists (hexamethonium, morphine, SR 48,968, spantide, RP 67,580) via intra-arterial or intrathecal routes.
  • Cystometric measurements to assess bladder function.

Related Experiment Videos

Main Results:

  • Intravesical capsaicin induced concentration-dependent bladder hyperactivity.
  • This hyperactivity was abolished by hexamethonium and morphine.
  • NK-2 receptor antagonists (SR 48,968, spantide) counteracted capsaicin-induced hyperactivity, while NK-1 antagonists (RP 67,580) did not.
  • Blockade of tachykinin receptors did not alter normal micturition reflex parameters.

Conclusions:

  • Capsaicin-sensitive nerves and NK-2 receptors play a significant role in bladder hyperactivity.
  • Tachykinins may lower the micturition reflex threshold via NK-2 receptor stimulation.
  • Intravesical capsaicin in rats serves as a valid model for studying bladder afferent activity and hyperactivity.