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Related Experiment Videos

Genotoxicity studies with chloroethane

R Ebert1, N Fedtke, H Certa

  • 1Hüls AG, Department of Toxicology, Marl, Germany.

Mutation Research
|July 1, 1994
PubMed
Summary
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Chloroethane (ECl) caused uterine cancer in female mice but not rats. Further genotoxicity tests in mice showed no evidence of ECl damage, suggesting genotoxicity is not the primary cause of mouse uterine cancer.

Area of Science:

  • Toxicology
  • Carcinogenesis
  • Genotoxicity

Background:

  • Chloroethane (ECl) exposure caused uterine cancer in female mice but not rats in a 2-year inhalation study.
  • The U.S. National Toxicology Program (NTP) concluded "clear evidence of carcinogenicity" in mice.

Purpose of the Study:

  • To investigate if genotoxic effects are responsible for ECl-induced uterine cancer in mice.
  • To evaluate the genotoxicity of ECl using in vitro and in vivo assays.

Main Methods:

  • In vitro HPRT test with CHO cells using a gas protocol.
  • In vivo/in vitro unscheduled DNA synthesis (UDS) assay in female B6C3F1 mice.
  • In vivo micronucleus assay in male and female B6C3F1 mice.

Main Results:

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  • ECl demonstrated mutagenic potential in the in vitro HPRT test.
  • No genotoxicity was detected in vivo using UDS or micronucleus assays, even at higher exposure concentrations.
  • In vivo genotoxic effects of ECl were below the detection limits of the assays used.

Conclusions:

  • Genotoxicity may not be a critical factor in the induction of uterine carcinomas by ECl in B6C3F1 mice.
  • The low in vivo genotoxic potential suggests alternative mechanisms for ECl carcinogenicity.