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Pathology of BPH

F Di Silverio1, G D'Eramo, G P Flammia

  • 1Department of Urology U. Bracci, University of Rome La Sapienza, Rome.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|December 1, 1993
PubMed
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Benign prostatic hyperplasia (BPH) involves both epithelial and stromal tissues. This study investigated epidermal growth factor (EGF) concentrations in different prostate zones, suggesting its role in BPH development.

Area of Science:

  • Urology
  • Pathology
  • Molecular Biology

Background:

  • Benign prostatic hyperplasia (BPH) is characterized by stromal and epithelial compartments.
  • The periurethral and transitional zones are notably affected in BPH.
  • Understanding the cellular origins and contributing factors in BPH is crucial.

Purpose of the Study:

  • To investigate the role of steroid receptors, 5 alpha reductase, DHT, and estrogen activity in BPH development.
  • To conduct an immunohistochemical study of epidermal growth factor (EGF) concentrations in distinct prostate zones of BPH samples.
  • To evaluate the stroma-epithelium ratio and its correlation with growth factor concentrations in BPH.

Main Methods:

  • Immunohistochemical analysis of BPH tissue samples from patients undergoing transvesical prostatectomy.

Related Experiment Videos

  • Regional evaluation of steroid receptors, 5 alpha reductase, DHT, and estrogen activity.
  • Quantification of epidermal growth factor (EGF) concentrations in periurethral, central, and pericapsular zones.

    • Main Results:

    • The study focused on the immunohistochemical assessment of epidermal growth factor (EGF) in specific prostate regions.
    • Analysis considered the stroma-epithelium ratio within BPH samples.
    • Investigations were performed on tissues from patients who underwent transvesical prostatectomy.

    Conclusions:

    • The periurethral zone is a key area involved in BPH.
    • Elevated concentrations of growth factors, such as EGF, in the periurethral region may indicate their involvement in BPH pathogenesis.
    • Further research into growth factor roles in BPH is warranted.