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Common structural patterns of cytokine outer surfaces
A I Denesyuk1, V P Zav'yalov, T Korpela
1Institute of Immunology, Moscow Region, Russia.
Biochemical and Biophysical Research Communications
|June 30, 1994
Abstract:
Schemes of the four-helix bundle surfaces of interleukin-2, -4, -5, granulocyte/macrophage-, granulocyte-, macrophage-colony-stimulating factor, interferon-beta, -gamma and growth hormone were designed. All cytokines appeared to have the structurally similar "holes" on the surfaces. They were suggested to serve as a part of the main receptor-binding sites.