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Solid cell nests of the thyroid: light microscopy and immunohistochemical profile
J Cameselle-Teijeiro1, J Varela-Durán, C Sambade
1Department of Pathology, University of Santiago Medical School and Hospital, Spain.
Human Pathology
|July 1, 1994
Summary
Solid cell nests (SCNs) in the thyroid contain two cell types, "main cells" and "C cells." These findings, along with mixed thyroid follicles, suggest SCNs are remnants of the ultimobranchial body.
Area of Science:
- Endocrinology
- Surgical Pathology
- Histology
Background:
- Solid cell nests (SCNs) are uncommon thyroid lesions.
- Their origin and nature remain debated.
- Mixed thyroid follicles are uniquely associated with SCNs.
Purpose of the Study:
- To characterize the cellular components and associated structures of SCNs.
- To investigate the immunohistochemical profile of SCNs and mixed thyroid follicles.
- To provide further evidence for the ultimobranchial origin of SCNs.
Main Methods:
- Morphological, histochemical, and immunohistochemical analysis of seven SCN cases.
- Light microscopy to identify cell types and structures.
- Immunohistochemistry to detect specific cellular markers.
Main Results:
- SCNs comprise "main cells" (CEA+, keratin+, neurotensin+, somatostatin+) and "C cells" (calcitonin+, CGRP+, chromogranin+).
- Mixed thyroid follicles contain intraluminal acid mucins.
- Adipose tissue and cartilage were observed in association with SCNs in two cases.
- SCN cells were negative for thyroglobulin; NSE-positive cells were found nearby.
Conclusions:
- SCNs and mixed thyroid follicles exhibit distinct cellular phenotypes.
- Immunohistochemical findings support the ultimobranchial body remnant theory for SCNs.
- SCNs and mixed thyroid follicles should be considered normal thyroid components.