[Tumor microvascular bed and its reactivity to vasoactive agents: measurement of tissue blood flow and...

Structural characteristics of tumor microvascular bed and its reactivity to vasoactive agents were studied by histological and ultrastructural examination and tissue blood flow measurement. The results showed that newly formed vessels in the tumor tissue consisted of a single layer of endothelial cells with multi-layer basement membranes and a few pericytes. Smooth muscle cells and nerve endings were absent. The tissue blood flow in highly proliferative parts of tumors was relatively constant and not influenced by tumor size, even though the distribution of neovasculature in tumor tissue was very uneven in distribution. The only vasoactive agent which can selectively increase the tumor blood flow was angiotensin II, whereas other adrenergic vasoconstrictors did not show this action.