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Related Experiment Video

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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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Myelin in multiple sclerosis is developmentally immature

M A Moscarello1, D D Wood, C Ackerley

  • 1Division of Biochemistry Research, Hospital for Sick Children, Toronto, Ontario, Canada.

The Journal of Clinical Investigation
|July 1, 1994
PubMed
Summary

Multiple sclerosis (MS) myelin is developmentally immature, arrested at early childhood levels. This immaturity may increase susceptibility to the factors causing MS disease.

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Area of Science:

  • Neuroimmunology
  • Developmental Neuroscience
  • Biochemistry

Background:

  • Multiple sclerosis (MS) etiology involves genetic, environmental, infective, and immunological factors.
  • These factors impact myelin sheath integrity, leading to demyelination.

Purpose of the Study:

  • To investigate the developmental stage of myelin in MS patients.
  • To determine if myelin in MS is developmentally immature.

Main Methods:

  • Protein chemical analysis of myelin basic protein (MBP) microheterogeneity.
  • Mass spectrometry to analyze NH2-terminal acylation of MBP components.
  • Differential scanning calorimetry to determine myelin phase transition temperature (Tc).
  • Immunogold electron microscopy using an antibody specific for MBP component "C-8".

Main Results:

  • MS myelin exhibits altered MBP microheterogeneity and NH2-terminal acylation.
  • A higher proportion of the least cationic MBP component ("C-8") was found in MS myelin.
  • The Tc of MS myelin correlated with the increased proportion of the "C-8" component.
  • Immunogold labeling patterns in MS myelin resembled those of a 2-year-old infant.

Conclusions:

  • Myelin in MS patients is developmentally immature, arrested at a stage similar to early childhood.
  • This developmental immaturity may render myelin more vulnerable to degradation.
  • Immature myelin may serve as the initial antigenic material triggering the immune response in MS.