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Related Experiment Video

Updated: Jun 1, 2026

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
10:01

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Published on: March 12, 2018

Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts

K Harada1, W Grossman, M Friedman

  • 1Charles A. Dana Research Institute, Boston, Massachusetts.

The Journal of Clinical Investigation
|August 1, 1994
PubMed
Summary

Basic fibroblast growth factor (bFGF) significantly reduced infarct size and improved myocardial function in chronically ischemic hearts. bFGF treatment also enhanced coronary blood flow and prevented hemodynamic decline during stress.

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Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Ischemic Heart Disease

Background:

  • Chronic myocardial ischemia leads to impaired heart function and increased infarct size.
  • Basic fibroblast growth factor (bFGF) is a potent angiogenic and mitogenic factor with potential therapeutic applications in cardiovascular disease.

Purpose of the Study:

  • To investigate the effects of basic fibroblast growth factor (bFGF) on regional myocardial function and blood flow in a porcine model of chronic myocardial ischemia.

Main Methods:

  • 26 pigs underwent proximal circumflex coronary artery (LCX) ameroid constriction to induce chronic ischemia.
  • bFGF was administered extraluminally to the LCX and left anterior descending (LAD) arteries in 13 pigs using heparin-alginate beads; 13 served as controls.
  • Regional myocardial function (percent fractional shortening) and coronary blood flow were assessed at rest and during rapid pacing.

Main Results:

  • bFGF treatment resulted in a fourfold reduction in left ventricular infarct size compared to controls (1.2% vs. 5.1% of LV mass).
  • bFGF-treated pigs showed better recovery of fractional shortening in the ischemic LCX area during pacing and less increase in left ventricular end-diastolic pressure.
  • Coronary blood flow in the LCX territory was improved during pacing in bFGF-treated pigs compared to controls.

Conclusions:

  • Periadventitial administration of bFGF effectively reduces infarct size and improves regional myocardial function and coronary blood flow in a porcine model of chronic ischemia.
  • bFGF treatment prevents pacing-induced hemodynamic deterioration, suggesting its therapeutic potential for ischemic heart disease.