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Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct

H H Chen¹, C H Chien, H M Liu

¹Division of Neurosurgery, National Cheng Kung University, Medical College, Tainan, Taiwan, Republic of China.

|August 1, 1994

Summary

Basic fibroblast growth factor (bFGF) may drive new blood vessel growth in brain infarcts. This study shows bFGF expression correlates with angiogenesis, suggesting its role in repair after stroke.

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Area of Science:

Neuroscience
Cell Biology
Pathology

Background:

Cerebral endothelial cells are normally quiescent but proliferate around brain infarcts.
The precise mechanism stimulating this proliferation remains unclear.

Purpose of the Study:

To investigate the relationship between angiogenesis and basic fibroblast growth factor (bFGF) expression in brain infarct models.
To identify the cell types involved in bFGF expression during infarct healing.

Main Methods:

A rat model of brain infarct was established using arterial ligation and occlusion.
Histological and immunohistochemical techniques were employed to analyze brain tissue from 1 to 14 days post-infarct.
Bromodeoxyuridine (BRdU) was used to label proliferating cells, serving as an S-phase marker.

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Main Results:

Increased bFGF immunoreactivity was detected in neurons near the infarct within 1 day, spreading to other neurons.
Blood vessels and glial cells around the infarct began incorporating BRdU after 2 days.
New capillaries and macrophages infiltrated the infarct within the first week, with macrophages, endothelial cells, and astrocytes showing bFGF expression.

Conclusions:

A spatial and temporal correlation exists between bFGF expression and angiogenesis in brain infarcts.
The findings suggest that bFGF produced by neurons, macrophages, and glial cells plays a role in angiogenesis following brain injury.