[Effect of substance P on survival of rats after cerebral ischemia: the effect depends on behavior type]

In rats with different behaviour types in tests of "open field" and "forced swimming", influence of intraperitoneal administration of P-substance (PC) neuropeptide to survival and structural-metabolic changes in brain after double-sided ligating of carotid arteries. It was established that PC exerts different influence on stability to circulating cerebral hypoxia according to behaviour types: it increases stability in rats with passive behaviour type, decrease stability in rats with active behaviour type and does not influence on rats with middle behaviour type. Results shows the necessity of individual approach to peptide use with the view to increase stabilization to cerebral ischemia.