Method for systemic anaphylactic challenge in the rat using subplantar route

S Levine1, A Saltzman

  • 1Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962.

Intravenous injection of antigen is the fastest and most effective way of eliciting anaphylactic shock in previously sensitized rats. When intravenous injection is difficult or undesirable, subplantar challenge is a preferable alternative to the intraperitoneal route.

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