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Updated: Aug 14, 2026

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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Method for systemic anaphylactic challenge in the rat using subplantar route
1Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962.
Journal of Immunological Methods
|August 1, 1994
Intravenous injection of antigen is the fastest and most effective way of eliciting anaphylactic shock in previously sensitized rats. When intravenous injection is difficult or undesirable, subplantar challenge is a preferable alternative to the intraperitoneal route.
Intravenous injection of antigen is the fastest and most effective way of eliciting anaphylactic shock in previously sensitized rats. When intravenous injection is difficult or undesirable, subplantar challenge is a preferable alternative to the intraperitoneal route.

