Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relationship between prostatic epithelial volume and serum prostate-specific antigen levels

H Lepor1, B Wang, E Shapiro

  • 1Department of Urology, Medical College of Wisconsin, Milwaukee.

Urology
|August 1, 1994
PubMed
Summary

Serum prostate-specific antigen (PSA) levels correlate most strongly with the transition zone (TZ) epithelial volume, not the peripheral zone (PZ) or total prostatic epithelial volume. This finding is crucial for understanding prostate cancer diagnostics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells.

International journal of oncology·2000
Same author

[Reconstruction of larynx with epiglottis and strip muscular flap after extended partial laryngectomy with T3 category].

Zhonghua er bi yan hou ke za zhi·2000
Same author

Hypersensitivity or development of antibodies to asparaginase does not impact treatment outcome of childhood acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2000
Same author

Development of an ELISA for paraquat; improvement of antibody characteristics by reversed affinity chromatography.

The Analyst·2000
Same author

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets.

Development (Cambridge, England)·2000
Same author

HIV-1 strains from a cohort of American subjects reveal the presence of a V2 region extension unique to slow progressors and non-progressors.

AIDS (London, England)·2000

Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • Prostate-specific antigen (PSA) is a key biomarker for prostate health.
  • Understanding the relationship between PSA and prostate anatomy is vital for accurate diagnosis.
  • Previous studies have explored PSA correlations with various prostate metrics.

Purpose of the Study:

  • To investigate the relationship between serum PSA levels and prostatic epithelial volumes.
  • To determine if PSA correlates more strongly with specific prostate zones (PZ vs. TZ).

Main Methods:

  • 42 men aged 50-79 with abnormal DRE or PSA > 4 ng/dL underwent TRUS and biopsy.
  • Prostate and transition zone volumes were calculated; epithelial density was analyzed.
  • Regression analysis was used to assess correlations between PSA and prostatic/epithelial volumes.

Related Experiment Videos

Main Results:

  • The peripheral zone (PZ) had significantly higher epithelial density and volume than the transition zone (TZ).
  • Serum PSA levels showed a significant correlation with TZ epithelial volume (r2 = 0.449) and TZ volume (r2 = 0.329).
  • No significant correlation was found between PSA and PZ volume, PZ epithelial volume, or total prostatic epithelial volume.

Conclusions:

  • Despite the PZ's larger epithelial volume, serum PSA is most strongly linked to the TZ epithelial volume.
  • This suggests the TZ plays a more significant role in PSA production relevant to diagnostic levels.