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Related Experiment Videos

Osteocalcin reference range in a Croatian population sample

V Kusec1, M Lukić, A Stavljenić-Rukavina

  • 1Clinical Institute of Laboratory Diagnosis, University Hospital Centre, Zagreb, Croatia.

Acta Medica Croatica : Casopis Hravatske Akademije Medicinskih Znanosti
|January 1, 1994
PubMed
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Osteocalcin levels did not differ between sexes in healthy adults. A decline in osteocalcin with age was observed only in females, with a validated reference range of 1-18 ng/mL.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Clinical Chemistry

Background:

  • Osteocalcin is a key non-collagenous matrix protein in bone.
  • Understanding osteocalcin reference ranges is crucial for diagnosing bone disorders.

Purpose of the Study:

  • To establish reference ranges for osteocalcin in healthy adults.
  • To investigate the influence of sex and age on osteocalcin concentrations.

Main Methods:

  • Radioimmunoassay (RIA) was used to measure serum osteocalcin.
  • 40 healthy males and 60 healthy females aged 21-90 years were included.

Main Results:

  • No significant sex-based differences in osteocalcin levels were found.
  • A negative, exponential age-related decrease in osteocalcin was observed exclusively in females.

Related Experiment Videos

  • Established reference range (1-18 ng/mL) validated in patients with bone metabolism disorders.

    • Conclusions:

    • Osteocalcin reference ranges are sex-independent in healthy adults.
    • Age-related decline in osteocalcin is specific to females.
    • The established reference range is reliable for clinical application.