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Related Experiment Videos

Intranephronic calculosis in the Brazilian squirrel monkey

M I Resnick, J Oliver, G W Drach

    Investigative Urology
    |January 1, 1978
    PubMed
    Summary

    Parathormone administration increased crystalline deposits in squirrel monkey kidneys, similar to human kidney stones. These findings highlight the squirrel monkey as a valuable model for studying renal stone disease.

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    Area of Science:

    • Nephrology
    • Biochemistry
    • Primate Models

    Background:

    • Renal stone disease, or kidney stones, affects a significant portion of the human population.
    • Understanding the etiology and mechanisms of kidney stone formation is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the effects of parathormone on kidney stone formation in Brazilian squirrel monkeys.
    • To evaluate the squirrel monkey as a model for human renal stone disease.

    Main Methods:

    • Kidney tissues from squirrel monkeys, before and after parathormone administration, were analyzed.
    • Techniques included microdissection, polarizing microscopy, alizarin red and von Kossa's stains, and microchemical analysis.

    Main Results:

    • Intralumenal crystalline-matrix masses were observed, with increased frequency after parathormone treatment.
    • Calcium, phosphorus, and urate salts were detected in the kidney tissues.
    • Refractile droplets positive for alizarin red were found in tubular cells of parathormone-treated animals.

    Conclusions:

    • The squirrel monkey exhibits urinary stone formation characteristics similar to humans.
    • This species serves as a relevant experimental model for studying renal stone disease.
    • Further research into the etiology, structure, composition, and control of stones in this model is warranted.

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