Epitope discovery using peptide libraries displayed on phage
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Updated: Oct 4, 2026

Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
Published on: December 6, 2017
R Cortese1, F Felici, G Galfre
1Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Roma, Italy.
Abstract:
Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.
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