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[Mott cells in the lymph]

A V Kuznetsov

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |January 1, 1993
    PubMed
    Summary
    This summary is machine-generated.

    Mott cells, immune cells previously unknown in lymph, were identified in rabbit cisterna chyli. Their numbers double in atherosclerosis, indicating an immune response to the condition.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Pathology

    Context:

    • Mott cells are a type of plasma cell characterized by abundant cytoplasm filled with immunoglobulins.
    • Lymphatic system plays a crucial role in immune surveillance and fluid balance.
    • Atherosclerosis is a chronic inflammatory disease affecting arteries.

    Purpose:

    • To investigate the presence and morphology of Mott cells in lymph.
    • To quantify Mott cells in the lymph of rabbits with and without atherosclerosis.
    • To explore the potential role of Mott cells in the immune response to atherosclerosis.

    Summary:

    • Mott cells were identified in rabbit lymph collected from the cisterna chyli using micropipettes.
    • Microscopic examination revealed Mott cells retain characteristic morphology, including rounded shape and cytoplasm divided into liquid spheres around a nucleus.

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  • A significant finding is the doubling of Mott cells in the lymph of rabbits with atherosclerosis compared to healthy controls.

    • Impact:

    • This study provides the first evidence of Mott cells within the lymphatic system.
    • The increased presence of Mott cells in atherosclerosis suggests their involvement in the immune system's reaction to this condition.
    • Further research may elucidate the specific functions of Mott cells in lymphatic immunity and atherogenesis.