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Related Experiment Videos

Early paradoxical decrease in serum somatomedin activity following injection of growth hormone

R M Schimpff, M Gourmelen, M Donnadieu

    The Journal of Clinical Endocrinology and Metabolism
    |January 1, 1978
    PubMed
    Summary
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    Intra-muscular growth hormone injections initially decreased somatomedin (SM) activity in children with growth hormone deficiency. This early decrease in SM activity appears linked to the deficiency itself.

    Area of Science:

    • Pediatric Endocrinology
    • Hormone Research
    • Growth & Development

    Background:

    • Growth hormone (GH) is crucial for childhood growth.
    • Somatomedin (SM) activity is a key indicator of GH action.
    • Understanding GH's immediate effects on SM is vital for treatment.

    Purpose of the Study:

    • To investigate the acute impact of intramuscular human growth hormone (hGH) on serum somatomedin (SM) activity.
    • To differentiate responses in children with total GH deficiency versus partial deficiency or constitutional short stature.

    Main Methods:

    • Administered intramuscular hGH (6 mg/m2) to pediatric participants.
    • Monitored serum SM activity at various time points post-injection.
    • Included children with hGH deficiency and constitutional short stature.

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    Main Results:

    • A significant early decrease (-34%) in SM activity was observed within 2 hours in children with total hGH deficiency.
    • SM activity rebounded significantly (+64%) above basal levels by 24 hours post-injection.
    • No similar early changes in SM activity were noted in children with partial hGH deficiency or constitutional short stature.

    Conclusions:

    • The acute administration of hGH can paradoxically cause a transient decrease in SM activity in GH-deficient children.
    • This early reduction in SM activity is likely a consequence of the underlying GH deficiency.
    • The findings highlight a complex, time-dependent relationship between GH administration and SM activity in pediatric endocrine disorders.