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Extrafollicular reticulum cells in pathologic lymph nodes

J Cho1, G Gong, G Choe

  • 1Department of Pathology, College of Medicine, Asan Medical Center, Ulsan University, Seoul, Korea.

Journal of Korean Medical Science
|February 1, 1994
PubMed
Summary
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Extrafollicular reticulum cells in lymph nodes show varied patterns based on pathology. Their distribution and expression of intermediate filaments, like cytokeratins, change in conditions such as hyperplasia, tuberculosis, and lymphoma.

Area of Science:

  • Immunohistochemistry
  • Lymph Node Pathology
  • Cell Biology

Background:

  • Extrafollicular reticulum cells in lymph nodes are heterogeneous.
  • These cells express cytokeratins, desmin, and/or vimentin as their intermediate filament profile.

Purpose of the Study:

  • To investigate the distribution of extrafollicular reticulum cells in human lymph nodes under various pathological conditions using immunohistochemistry.
  • To identify the intermediate filament profiles of these cells in different disease states.

Main Methods:

  • Immunohistochemical study of human lymph node samples.
  • Inclusion of samples from simple reactive lymph nodes, follicular hyperplasia, necrotizing lymphadenitis, tuberculous lymphadenitis, malignant lymphoma, and metastatic adenocarcinoma.
  • SDS-PAGE and immunoblotting to identify cytokeratin polypeptides.

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Main Results:

  • In follicular hyperplasia, cytokeratin/desmin-expressing reticulum cells formed a dendritic meshwork in specific lymph node regions.
  • Distribution patterns were altered in necrotizing and tuberculous lymphadenitis, with increased cell presence.
  • The reticular meshwork was obliterated in lymphomas and metastatic carcinoma, with rare reticulum cells found within tumors.

Conclusions:

  • Extrafollicular reticulum cells exhibit characteristic distribution patterns in various pathological conditions of the lymph node.
  • These cells may play a role in the pathogenesis of these lymph node pathologies.