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Emphysematous pyelonephritis successfully treated with nephrectomy and granulocyte colony-stimulating factor
1Department of Internal Medicine, Tokyo Metropolitan Bokuto General Hospital.
Internal Medicine (Tokyo, Japan)
|April 1, 1994
Summary
This case study shows that recombinant human granulocyte colony-stimulating factor (rhG-CSF) can effectively treat severe infections in diabetic patients. It highlights rhG-CSF as a potential therapy even without neutropenia.
Area of Science:
- Nephrology
- Infectious Diseases
- Endocrinology
Background:
- Diabetic ketoacidosis (DKA) and emphysematous pyelonephritis are severe complications in diabetic patients.
- Escherichia coli is a common pathogen causing urinary tract infections and pyelonephritis.
Observation:
- A 58-year-old female patient presented with DKA and emphysematous pyelonephritis.
- The infection was caused by Escherichia coli.
Findings:
- The patient underwent successful treatment including nephrectomy and antibiotics.
- Adjunctive therapy with recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered.
- rhG-CSF treatment was effective in resolving the severe infection.
Implications:
- rhG-CSF may be a valuable therapeutic option for severe infections in diabetic patients.
- The benefits of rhG-CSF may extend to patients without neutropenia.
- This case suggests a potential role for rhG-CSF in managing complex diabetic emergencies.