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Related Experiment Videos

A new steroid-eluting screw-in electrode

G Fröhlig1, B Schwaab, H Schwerdt

  • 1Medizinische Universitätsklinik III, Homburg, Germany.

Pacing and Clinical Electrophysiology : PACE
|June 1, 1994
PubMed
Summary

A novel steroid-eluting active fixation atrial lead demonstrated significantly lower pacing thresholds compared to conventional leads over one year. This new design offers improved atrial pacing performance in dual chamber pacing systems.

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Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Atrial lead performance is critical for dual chamber pacing systems.
  • Conventional atrial leads can present challenges in maintaining stable pacing thresholds.
  • Steroid elution from pacing leads has shown potential to reduce local inflammation and improve performance.

Purpose of the Study:

  • To compare the acute and long-term performance of a new steroid-eluting active fixation atrial lead with a conventional passive fixation lead.
  • To evaluate sensing and pacing thresholds of the novel lead design in the atrial position.

Main Methods:

  • A prospective study comparing a steroid-eluting active fixation lead (Medtronic model 5078) with a conventional non-steroid, passive fixation lead (Biotronik model Y 60 BP).

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  • Both lead types were implanted in the atrial position of dual chamber pacing systems with identical tined ventricular leads.
  • Sensing and pacing thresholds were recorded intraoperatively and followed for 1 year via pulse generator telemetry.

    • Main Results:

    • No significant difference in intraoperative electrogram amplitudes or 1-year sensing thresholds between the two lead groups.
    • The new steroid-eluting active fixation lead showed significantly lower initial atrial pacing thresholds compared to the conventional lead (P < 0.05).
    • Over 1 year, the steroid-eluting lead maintained significantly lower and more stable atrial pacing thresholds (P < 0.01) with less variability.

    Conclusions:

    • The novel steroid-eluting active fixation atrial lead provides superior atrial pacing performance compared to conventional leads.
    • This design may lead to more stable and reliable atrial pacing over the long term.
    • Steroid elution in active fixation leads is a promising strategy for enhancing pacing efficacy.