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Chloride secretion and function of serous and mucous cells of human airway glands
W E Finkbeiner1, B Q Shen, J H Widdicombe
1Cardiovascular Research Institute, University of California, San Francisco 94143-0130.
The American Journal of Physiology
|August 1, 1994
Abstract:
Cells from the acini of human tracheal glands were grown in culture to produce confluent cell sheets of mucous or mixed seromucous phenotype. Levels of mediator-induced Cl secretion in mucous cells were 2-18% those of seromucous cells. Levels of the cystic fibrosis transmembrane conductance regulator (an apical membrane Cl channel) were also much less in mucous than in seromucous cells. These results suggest that serous cells are more important than mucous cells in providing the fluid component of gland secretions.