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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
[Classification of hepatitis C virus into two major groups in serologic activity: correlation with response to
T Matsushima1, Y Karino, S Hige
1Third Department of Internal Medicine, Hokkaido University Medical School.
Abstract:
Genotypes of HCV have been reported to be one of the predictors of response to IFN therapy in patients with chronic hepatitis C. HCV genotypes were determined enzyme-linked immunoblot assay based on group I and II specific recombinant peptides of the NS-4 region (amino acid No. 1676-1670). We examined the correlation between HCV groups and response to IFN in patients with chronic hepatitis C. Among the 84 patients with chronic hepatitis C who underwent IFN treatment, 16 of 51 (31.4%) patients with group I and 12 of 23 (52.2%) patients with group II showed complete sustained response. These results suggest that HCV group assay may improve the ability to predict IFN treatment outcomes.
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