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Regional oxygen consumption persists in dyskinetic canine myocardium
C W Buffington1, D P Strum, S Watanabe
1Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania.
Journal of Cardiovascular Pharmacology
|July 1, 1994
Abstract:
Regional myocardial O2 consumption was measured in anesthetized dogs both in baseline conditions and during intracoronary infusion of lidocaine, verapamil, sodium citrate, or 2,3-butanedione-monoxime (BDM). Despite regional hypokinesis and dyskinesis during drug infusion, regional O2 consumption was reduced only 30-40% by lidocaine, verapamil, and citrate and not at all by BDM. These results cast doubt on an important assumption of the "hibernation" theory: the protective matching of regional perfusion and contraction.