Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Random-coil model for glomerular sieving of dextran

J D Oliver1, W M Deen

  • 1Department of Chemical Engineering, Massachussetts Institute of Technology, Cambridge 02139.

Bulletin of Mathematical Biology
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VBNC, previously unrecognized in the life cycle of <i>Porphyromonas gingivalis?</i>

Journal of oral microbiology·2022
Same author

Molecular Diagnostics and In Utero Therapeutics for Orofacial Clefts.

Journal of dental research·2020
Same author

Differences in Abundances of Total Vibrio spp., V. vulnificus, and V. parahaemolyticus in Clams and Oysters in North Carolina.

Applied and environmental microbiology·2016
Same author

Viable but Nonculturable and Persister Cells Coexist Stochastically and Are Induced by Human Serum.

Infection and immunity·2015
Same author

Development of a matrix tool for the prediction of Vibrio species in oysters harvested from North Carolina.

Applied and environmental microbiology·2014
Same author

Occurrence of Vibrio vulnificus in mussel farms from the Varano lagoon environment.

Letters in applied microbiology·2010

Dextran transport across kidney filters is faster than predicted by models. Attractive interactions between dextran and filter pores explain this enhanced glomerular filtration.

Area of Science:

  • Biophysics
  • Renal Physiology
  • Polymer Science

Background:

  • Dextran is a standard molecule for studying glomerular filtration selectivity.
  • Existing models based on solid spheres are inadequate for linear polymers like dextran, which behave as random coils.

Purpose of the Study:

  • To develop a more accurate model for glomerular filtration of random-coil macromolecules.
  • To investigate the transport mechanisms of dextran across the glomerular capillary wall.

Main Methods:

  • Simulated equilibrium partitioning of random coils in pores using Monte Carlo calculations.
  • Combined simulations with hydrodynamic theory for polymer motion in pores.
  • Modeled attractive interactions between dextran and pore walls using a square-well potential.

Related Experiment Videos

Main Results:

  • Transport rates predicted for neutral random coils were lower than observed dextran transport.
  • Attractive interactions between dextran and pore walls were necessary to match experimental data.
  • The developed random-coil model with attractive interactions accurately represented dextran sieving in rats.

Conclusions:

  • Glomerular filtration of dextran is facilitated by attractive interactions with the pore wall.
  • The random-coil model with attractive forces provides a better framework for understanding macromolecular filtration.
  • Further research is needed to explore the limitations of this modeling approach.