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[Influence of mediators on plasminogen activator release]
Acta Biologica Et Medica Germanica
|January 1, 1978
Summary
Histamine and plasma kinins stimulate plasminogen activator release in pig ears, an effect blocked by antihistamines. This release correlates with increased capillary permeability, highlighting mediator roles in vascular responses.
Area of Science:
- Biochemistry
- Physiology
Context:
- Investigating the role of low molecular weight mediators in regulating plasminogen activator release.
- Utilizing an isolated perfused pig ear model to study localized physiological responses.
Purpose:
- To determine which specific low molecular weight mediators influence plasminogen activator release.
- To correlate mediator-induced activator release with changes in capillary permeability.
Summary:
- Histamine and plasma kinins (bradykinin, kallidin) demonstrated a dose-dependent release of plasminogen activator.
- Eledoisin, among tested biogenic peptides, also released plasminogen activator.
- Serotonin and prostaglandins showed no significant effect at tested concentrations.
- Mediators that increased activator release also enhanced capillary permeability.
Impact:
- Provides insights into the biochemical pathways regulating fibrinolysis.
- Identifies specific vasoactive mediators involved in plasminogen activator release.
- Suggests a link between mediator-induced vascular permeability and fibrinolytic system activation.